Product Description: translation initiation factor SUI1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0001731 | formation of translation preinitiation complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.27 | 0.86 |
| Trophozoite | expressed | 0.34 | 0.80 |
| Schizont | expressed | 0.19 | 0.88 |
| Gametocyte | expressed | 0.46 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0907600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.765 | #Insertions: 3
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0809000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0809000)
Modification: Disrupted | RMgm-2336
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I375
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102936
Most Similar Human Ortholog: A0A087X1L6
TM-align score: 0.59 | RMSD: 3.06
Seq Identity: 0.24 | Length: 58 / 818
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143486 | eukaryotic translation initiation factor 2D |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 54 | 42 | 73 |
| disruptive | 38 | 137 | 93 | 184 |
| missense | 23 | 125 | 87 | 169 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 111 | 45 | 76 |
| disruptive | 64 | 306 | 143 | 273 |
| missense | 43 | 263 | 123 | 196 |
PlasmoDB Total SNPs: 206
Non-coding: 132 | Synonymous: 43 | Nonsynonymous: 31 | Stop Codon: 0
Protein Length: 818 | Molecular Weight (kDa): 95.282
UniProt ID(s): Q8I375
PDB ID(s): None
Isoelectric Point: 8.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001950 | SUI1 domain |
| InterPro | IPR015947 | PUA-like superfamily |
| InterPro | IPR036877 | SUI1 domain superfamily |
| InterPro | IPR039757 | Eukaryotic translation initiation factor 2D |
| InterPro | IPR039759 | Eukaryotic translation initiation factor 2D, SUI1 domain |
| InterPro | IPR041366 | Pre-PUA domain |
| PFam | PF01253 | SUI1 domain |
| PFam | PF17832 | Pre-PUA domain |
| Superfamily | SSF55159 | SUI1 domain superfamily |
| Superfamily | SSF88697 | PUA-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |