Product Description: proteasome activator 28
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005654 | nucleoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:0008537 | proteasome activator complex |
| Function | GO:0061133 | endopeptidase activator activity |
| Process | GO:0010950 | positive regulation of endopeptidase activity |
| Process | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| Process | GO:0061136 | regulation of proteasomal protein catabolic process |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.55 | 0.73 |
| Trophozoite | expressed | 0.48 | 0.72 |
| Schizont | expressed | 0.21 | 0.85 |
| Gametocyte | not expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0907700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.278 | MFS: -2.289 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0809100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0809100)
Modification: Disrupted | RMgm-2337
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I374
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104507
Most Similar Human Ortholog: P61289
TM-align score: 0.77 | RMSD: 2.69
Seq Identity: 0.34 | Length: 218 / 279
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000131467 | proteasome activator subunit 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 18 | 14 | 23 |
| disruptive | 4 | 7 | 4 | 16 |
| missense | 4 | 7 | 4 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 46 | 13 | 17 |
| disruptive | 5 | 22 | 20 | 52 |
| missense | 5 | 21 | 16 | 35 |
PlasmoDB Total SNPs: 149
Non-coding: 128 | Synonymous: 15 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 279 | Molecular Weight (kDa): 33.126
UniProt ID(s): Q8I374
PDB ID(s): 6DFK
Isoelectric Point: 6.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003186 | Proteasome activator PA28, C-terminal domain |
| InterPro | IPR009077 | Proteasome activator PA28 |
| InterPro | IPR036252 | Proteasome activator superfamily |
| PFam | PF02252 | Proteasome activator PA28, C-terminal domain |
| Superfamily | SSF47216 | Proteasome activator superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31384003 | The structure of the PA28-20S proteasome complex from Plasmodium falciparum andimplications for proteostasis. | Xie SC, Metcalfe RD, ..., Tilley L | 10.1038/s41564-019-0524-4 |