Product Description: ribosomal protein L35, apicoplast, putative
SignalP Peptide: MKCLLVKLFMLIFIRSYTYA
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.21 | 0.90 |
| Trophozoite | possibly expressed | 0.68 | 0.62 |
| Schizont | possibly expressed | 0.65 | 0.63 |
| Gametocyte | expressed | 0.51 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0907800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.177 | MFS: -2.729 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0809200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I373
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 14 | 6 | 18 |
| disruptive | 4 | 22 | 19 | 38 |
| missense | 4 | 22 | 19 | 37 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 30 | 12 | 24 |
| disruptive | 12 | 52 | 28 | 45 |
| missense | 9 | 45 | 25 | 38 |
PlasmoDB Total SNPs: 123
Non-coding: 103 | Synonymous: 12 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 191 | Molecular Weight (kDa): 22.743
UniProt ID(s): Q8I373
PDB ID(s): None
Isoelectric Point: 11.28
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001706 | Ribosomal protein L35, non-mitochondrial |
| InterPro | IPR018265 | Ribosomal protein L35, conserved site |
| InterPro | IPR021137 | Ribosomal protein L35 |
| InterPro | IPR037229 | Ribosomal protein L35 superfamily |
| PFam | PF01632 | Ribosomal protein L35 |
| Superfamily | SSF143034 | Ribosomal protein L35 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |