Product Description: peptide deformylase
SignalP Peptide: MLMYYSLFLFNLIICCNVTSIYG
# Transmembrane Domains: 1
EC Numbers: 3.5.1.88 (Peptide deformylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0008198 | ferrous iron binding |
| Process | GO:0031365 | N-terminal protein amino acid modification |
| Process | GO:0043686 | co-translational protein modification |
| Process | GO:0018206 | peptidyl-methionine modification |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.95 | 0.50 |
| Schizont | expressed | 0.30 | 0.81 |
| Gametocyte | expressed | 0.34 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0907900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -3.244 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0809300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I372
"Best" AlphaFill ligand hit: MHA (n-(2-acetamido)iminodiacetic acid, Local RMSD=0.05) with 1IX1 (Global RMSD=2.52)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.5.1.88 | peptide deformylase | EDTAZnCl2thiramLBM415BB-3497LBM-415BB83698LBK-611BB-83698BB-81384VRC-3375VRC-4307... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P9WIJ3 | Peptide deformylase | Mycobacterium tuberculosis | OMA, OrthoMCL, OrthoMCL BLAST | CHEMBL443904CHEMBL482179CHEMBL482180CHEMBL519613... |
| P0A6K3 | Peptide deformylase | Escherichia coli | OMA, OrthoMCL, OrthoMCL BLAST | SB-485345SB-543668SB-505684CHEMBL51705... |
| Q9I7A8 | Peptide deformylase | Pseudomonas aeruginosa | OMA, OrthoMCL, OrthoMCL BLAST | CHEMBL1643864CHEMBL1643863CHEMBL1643862CHEMBL1643861... |
| P44786 | Peptide deformylase | Haemophilus influenzae | OMA, OrthoMCL BLAST | SB-485345SB-543668SB-505684 |
| Q9FV53 | Peptide deformylase 1A, chloroplastic/mitochondrial | Arabidopsis thaliana | OrthoDB, OrthoMCL, OrthoMCL BLAST | ACTINONIN |
| Q9F2F0 | Peptide deformylase | OrthoMCL BLAST | CHEMBL2032111CHEMBL2032129CHEMBL2032148CHEMBL2032110... | |
| P68826 | Peptide deformylase | Staphylococcus aureus (strain Mu50 / ATCC 700699) | OrthoMCL BLAST | CHEMBL29911CHEMBL26038CHEMBL30051CHEMBL282858... |
| Q9JN24 | Peptide deformylase | OrthoMCL BLAST | CHEMBL92954CHEMBL3296771-{(R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoyl}-pyrrolidine-2-carboxylic acid (S)-dimethyl-amideCHEMBL92198... | |
| Q9HBH1 | Peptide deformylase, mitochondrial | Homo sapiens | OrthoMCL BLAST | ACTINONINBB-3554BB-3497ACTINONIN... |
| P68825 | Peptide deformylase | Staphylococcus aureus | OrthoMCL BLAST | SB-485345SB-543668SB-505684BB-83698... |
| Q8DP79 | Peptide deformylase | Streptococcus pneumoniae (strain ATCC BAA-255 / R6) | OrthoMCL BLAST | SB-485345SB-543668SB-505684PDF inhibitor, compound 1... |
Ortholog Group (OrthoMCL): OG6_101584
Most Similar Human Ortholog: Q9HBH1
TM-align score: 0.60 | RMSD: 2.60
Seq Identity: 0.31 | Length: 159 / 241
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000258429 | peptide deformylase, mitochondrial |
Protein Length: 241 | Molecular Weight (kDa): 28.394
UniProt ID(s): Q8I372
Isoelectric Point: 9.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR023635 | Peptide deformylase |
| InterPro | IPR036821 | Peptide deformylase superfamily |
| PFam | PF01327 | Peptide deformylase |
| Superfamily | SSF56420 | Peptide deformylase superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 21 | 11 | 12 |
| disruptive | 2 | 20 | 10 | 24 |
| missense | 2 | 19 | 10 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 31 | 7 | 20 |
| disruptive | 7 | 36 | 19 | 45 |
| missense | 6 | 32 | 18 | 39 |
PlasmoDB Total SNPs: 102
Non-coding: 88 | Synonymous: 11 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11747293 | Characterization of an eukaryotic peptide deformylase from Plasmodium falciparum. | Bracchi-Ricard V, Nguyen KT, ..., Pei D | 10.1006/abbi.2001.2631 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15279947 | Localization of organellar proteins in Plasmodium falciparum using a novel set oftransfection vectors and a new immunofluorescence fixation method. | Tonkin CJ, van Dooren GG, ..., McFadden GI | 10.1016/j.molbiopara.2004.05.009 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |