About Gene List

PF3D7_0908100

Genome location: Pf3D7_09_v3:373,762..375,586(-)

Genome classification: Core

Function and Localization

Product Description: apicoplast integral membrane protein, putative

SignalP Peptide: MNTHFLLWLILLICYKNVEC

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite possibly expressed 0.12 0.92
Schizont possibly expressed 0.12 0.92
Gametocyte possibly expressed 0.38 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0908100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.266 | MFS: -2.484 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0809500)

  • Relative Growth Rate: 1.03 ± 0.13
  • Confidence: 5.50

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0809500)

Modification: Tagged | RMgm-4323

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H525

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533428

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 23 15 30
disruptive 10 60 46 94
missense 10 60 41 91

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 57 17 39
disruptive 24 143 77 151
missense 23 127 68 127

PlasmoDB Total SNPs: 101

Non-coding: 70 | Synonymous: 18 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 476 | Molecular Weight (kDa): 57.686

UniProt ID(s): C0H525

PDB ID(s): None

Isoelectric Point: 10.15

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
28902970 A genetic screen in rodent malaria parasites identifies five new apicoplastputative membrane transporters, one of which is essential in human malariaparasites Sayers CP, Mollard V, ..., Goodman CD 10.1111/cmi.12789
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895