Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | not expressed | 0.05 | 0.98 |
Trophozoite | possibly expressed | 0.34 | 0.79 |
Schizont | expressed | 0.89 | 0.54 |
Gametocyte | possibly expressed | 0.50 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0908200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.212 | MFS: -2.863 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I369
"Best" AlphaFill ligand hit: BU3 ((r,r)-2,3-butanediol, Local RMSD=10.83) with 3W3G (Global RMSD=18.88)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 13 | 92 | 35 | 114 |
disruptive | 80 | 230 | 162 | 306 |
missense | 37 | 180 | 133 | 256 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 30 | 166 | 71 | 112 |
disruptive | 146 | 498 | 232 | 461 |
missense | 73 | 391 | 183 | 314 |
PlasmoDB Total SNPs: 297
Non-coding: 129 | Synonymous: 90 | Nonsynonymous: 78 | Stop Codon: 0
Protein Length: 1505 | Molecular Weight (kDa): 180.686
UniProt ID(s): Q8I369
PDB ID(s): None
Isoelectric Point: 9.18
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |