PF3D7_0908300

Genome location: Pf3D7_09_v3:383,132..386,854(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0908300.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.143 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H526

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108396

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	26	10	15
disruptive	2	8	11	34
missense	2	8	10	29

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	39	16	16
disruptive	5	35	30	48
missense	3	28	24	34

PlasmoDB Total SNPs: 253

Non-coding: 231 | Synonymous: 21 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 305 | Molecular Weight (kDa): 35.953

UniProt ID(s): C0H526

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009457	Domain of unknown function DUF1084
InterPro	IPR040226	THH1/TOM1/TOM3
PFam	PF06454	Domain of unknown function DUF1084
Superfamily	N/A	N/A