About Gene List

PF3D7_0908500

Genome location: Pf3D7_09_v3:389,017..398,034(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.07 0.97
Trophozoite not expressed 0.16 0.91
Schizont expressed 1.51 0.50
Gametocyte not expressed 0.60 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0908500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.441 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H527

"Best" AlphaFill ligand hit: MPO (3[n-morpholino]propane sulfonic acid, Local RMSD=0.68) with 4LXT (Global RMSD=15.42)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533202

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 134 82 154
disruptive 62 346 194 455
missense 52 336 187 424

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 31 255 101 175
disruptive 114 658 310 546
missense 92 611 282 464

PlasmoDB Total SNPs: 513

Non-coding: 321 | Synonymous: 108 | Nonsynonymous: 84 | Stop Codon: 0

Protein Information

Protein Length: 1993 | Molecular Weight (kDa): 240.186

UniProt ID(s): C0H527

PDB ID(s): None

Isoelectric Point: 9.22

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095