Product Description: mitochondrial carrier protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0005347 | ATP transmembrane transporter activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.15 | 0.93 |
| Trophozoite | expressed | 0.33 | 0.80 |
| Schizont | expressed | 0.11 | 0.92 |
| Gametocyte | possibly expressed | 0.26 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0908800
Resistome Missense Mutations: V564E
Resistome Compounds with Missense Mutations: Verapamil
Resistome # Samples with Disruptive Mutations: 5 (4 missense, 4 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -3.009 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I364
"Best" AlphaFill ligand hit: CXT (carboxyatractyloside, Local RMSD=0.26) with 4C9J (Global RMSD=4.36)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100689
Most Similar Human Ortholog: A0A804HI56
TM-align score: 0.68 | RMSD: 2.78
Seq Identity: 0.32 | Length: 286 / 590
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000085491 | solute carrier family 25 member 24 |
| ENSG00000125648 | solute carrier family 25 member 23 |
| ENSG00000148339 | solute carrier family 25 member 25 |
| ENSG00000284468 | solute carrier family 25 member 24 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 43 | 18 | 44 |
| disruptive | 15 | 59 | 38 | 86 |
| missense | 10 | 55 | 37 | 74 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 69 | 25 | 46 |
| disruptive | 24 | 141 | 80 | 189 |
| missense | 17 | 115 | 59 | 113 |
PlasmoDB Total SNPs: 63
Non-coding: 17 | Synonymous: 37 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 590 | Molecular Weight (kDa): 70.055
UniProt ID(s): Q8I364
PDB ID(s): None
Isoelectric Point: 9.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002067 | Mitochondrial carrier protein |
| InterPro | IPR018108 | Mitochondrial substrate/solute carrier |
| InterPro | IPR023395 | Mitochondrial carrier domain superfamily |
| PFam | PF00153 | Mitochondrial substrate/solute carrier |
| Superfamily | SSF103506 | Mitochondrial carrier domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |