PF3D7_0909000

Genome location: Pf3D7_09_v3:410,326..413,841(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.14	0.90
Gametocyte	possibly expressed	0.82	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0909000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.265 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I362

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532970

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	44	32	75
disruptive	21	100	54	126
missense	14	89	50	111

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	93	57	77
disruptive	40	216	89	236
missense	23	186	74	170

PlasmoDB Total SNPs: 185

Non-coding: 75 | Synonymous: 65 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 1012 | Molecular Weight (kDa): 120.842

UniProt ID(s): Q8I362

PDB ID(s): None

Isoelectric Point: 8.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A