Product Description: apoptosis-related protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.09 | 0.96 |
| Trophozoite | not expressed | 0.11 | 0.93 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | not expressed | 0.07 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0909300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.353 | MFS: -2.736 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I359
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101501
Most Similar Human Ortholog: K7EQA1
TM-align score: 0.67 | RMSD: 1.63
Seq Identity: 0.30 | Length: 67 / 131
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105185 | programmed cell death 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 196
Non-coding: 184 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 2
Protein Length: 131 | Molecular Weight (kDa): 15.735
UniProt ID(s): Q8I359
PDB ID(s): None
Isoelectric Point: 6.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002836 | PDCD5-like |
| InterPro | IPR036883 | PDCD5-like superfamily |
| PFam | PF01984 | PDCD5-like |
| Superfamily | SSF46950 | PDCD5-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 17182255 | Overexpression, purification and localization of apoptosis related protein fromPlasmodium falciparum. | Guha M, Choubey V, ..., Bandyopadhyay U | 10.1016/j.pep.2006.11.004 |