Product Description: exoribonuclease, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.13.1 (Exoribonuclease II)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0004534 | 5'-3' exoribonuclease activity |
| Function | GO:0003723 | RNA binding |
| Process | GO:0000956 | nuclear-transcribed mRNA catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.76 | 0.65 |
| Trophozoite | expressed | 0.87 | 0.53 |
| Schizont | expressed | 0.42 | 0.74 |
| Gametocyte | expressed | 0.75 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0909400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.137 | MFS: -2.944 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0810600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I358
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.13.1 | exoribonuclease II | SDSEDTArRNAsucrosePoly(U)Poly(G)sperminepoly(dC)nicotinamidetrichostatin A5'-capped mRNAds plasmid DNA... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100417
Most Similar Human Ortholog: F8WDA0
TM-align score: 0.90 | RMSD: 1.66
Seq Identity: 0.54 | Length: 105 / 1311
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000088930 | 5-3 exoribonuclease 2 |
| ENSG00000114127 | 5-3 exoribonuclease 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 80 | 62 | 83 |
| disruptive | 28 | 116 | 74 | 196 |
| missense | 19 | 99 | 66 | 159 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 187 | 49 | 85 |
| disruptive | 55 | 291 | 131 | 370 |
| missense | 32 | 232 | 100 | 233 |
PlasmoDB Total SNPs: 165
Non-coding: 77 | Synonymous: 46 | Nonsynonymous: 42 | Stop Codon: 0
Protein Length: 1311 | Molecular Weight (kDa): 154.959
UniProt ID(s): Q8I358
PDB ID(s): None
Isoelectric Point: 7.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004859 | Putative 5-3 exonuclease |
| InterPro | IPR017151 | 5'-3' exoribonuclease type 2 |
| InterPro | IPR027073 | 5'-3' exoribonuclease |
| InterPro | IPR041412 | Xrn1, helical domain |
| PFam | PF03159 | Putative 5-3 exonuclease |
| PFam | PF17846 | Xrn1, helical domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |