Product Description: subpellicular microtubule protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005856 | cytoskeleton |
| Component | GO:0020025 | subpellicular microtubule |
| Function | GO:0008017 | microtubule binding |
| Process | GO:0034453 | microtubule anchoring |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.01 | 1.00 |
| Schizont | expressed | 0.12 | 0.91 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0909500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0810700)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0810700)
Modification: Disrupted | RMgm-5349
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I357
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105719
Most Similar Human Ortholog: H3BMC1
TM-align score: 0.35 | RMSD: 2.29
Seq Identity: 0.00 | Length: 20 / 489
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000155875 | stabilizer of axonemal microtubules 1 |
| ENSG00000188659 | stabilizer of axonemal microtubules 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 12 | 5 | 22 |
| disruptive | 3 | 23 | 23 | 45 |
| missense | 3 | 22 | 23 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 24 | 11 | 20 |
| disruptive | 4 | 58 | 31 | 60 |
| missense | 4 | 50 | 30 | 45 |
PlasmoDB Total SNPs: 152
Non-coding: 72 | Synonymous: 59 | Nonsynonymous: 21 | Stop Codon: 0
Protein Length: 489 | Molecular Weight (kDa): 56.788
UniProt ID(s): Q8I357
PDB ID(s): None
Isoelectric Point: 8.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR033336 | Stabilizer of axonemal microtubules 1/2 |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 22021240 | SPM1 stabilizes subpellicular microtubules in Toxoplasma gondii. | Tran JQ, Li C, ..., Morrissette NS | 10.1128/EC.05161-11 |
| 26292257 | Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for VaccineDevelopment. | Aguiar JC, Bolton J, ..., Richie TL | 10.1371/journal.pone.0136109 |
| 37398039 | The protein phosphatase PPKL is a key regulator of daughter parasite developmentin Toxoplasma gondii | Yang C, Doud EH, Sampson E, Arrizabalaga G | 10.1101/2023.06.13.544803 |
| 37877735 | The protein phosphatase PPKL is a key regulator of daughter parasite developmentin Toxoplasma gondii | Yang C, Doud EH, Sampson E, Arrizabalaga G | 10.1128/mbio.02254-23 |
| 34031406 | Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondiiidentifies their microtubule inner proteins | Wang X, Fu Y, ..., Zhang R | 10.1038/s41467-021-23351-1 |