PF3D7_0909600

Genome location: Pf3D7_09_v3:432,221..435,442(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.32	0.84
Trophozoite	expressed	0.77	0.59
Schizont	expressed	0.76	0.60
Gametocyte	expressed	0.73	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0909600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.061 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I356

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532698

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	26	19	35
disruptive	6	26	20	47
missense	6	26	19	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	55	30	47
disruptive	16	67	40	116
missense	9	51	32	94

PlasmoDB Total SNPs: 191

Non-coding: 152 | Synonymous: 32 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 604 | Molecular Weight (kDa): 72.245

UniProt ID(s): Q8I356

PDB ID(s): None

Isoelectric Point: 8.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A