PF3D7_0909700

Genome location: Pf3D7_09_v3:437,400..444,712(+)

Genome classification: Core

Function and Localization

Product Description: FHA domain protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0009410	response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.71	0.66
Trophozoite	possibly expressed	0.22	0.87
Schizont	expressed	0.47	0.73
Gametocyte	expressed	0.58	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0909700

Resistome Missense Mutations: L95R, G720E

Resistome Compounds with Missense Mutations: MMV668399

Resistome # Samples with Disruptive Mutations: 11 (2 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.992 | MFS: -2.556 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0810900)

Relative Growth Rate: 0.22 ± 0.16
Confidence: 5.10

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I355

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119641

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	78	37	68
disruptive	39	190	106	204
missense	29	149	82	160

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	145	54	81
disruptive	77	423	150	408
missense	50	321	111	222

PlasmoDB Total SNPs: 402

Non-coding: 275 | Synonymous: 90 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 1036 | Molecular Weight (kDa): 120.06

UniProt ID(s): Q8I355

PDB ID(s): None

Isoelectric Point: 6.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000253	Forkhead-associated (FHA) domain
InterPro	IPR008984	SMAD/FHA domain superfamily
InterPro	IPR011016	Zinc finger, RING-CH-type
PFam	PF00498	Forkhead-associated (FHA) domain
PFam	PF12906	Zinc finger, RING-CH-type
Superfamily	SSF49879	SMAD/FHA domain superfamily
Superfamily	SSF57850

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
29326268	Mapping the malaria parasite druggable genome by using in vitro evolution andchemogenomics.	Cowell AN, Istvan ES, ..., Winzeler EA	10.1126/science.aan4472