Product Description: small nuclear ribonucleoprotein Sm D3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0034719 | SMN-Sm protein complex |
| Component | GO:0005685 | U1 snRNP |
| Component | GO:0005689 | U12-type spliceosomal complex |
| Component | GO:0005686 | U2 snRNP |
| Component | GO:0005687 | U4 snRNP |
| Component | GO:0005682 | U5 snRNP |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0000243 | commitment complex |
| Component | GO:0005634 | nucleus |
| Component | GO:0034715 | pICln-Sm protein complex |
| Component | GO:0071011 | precatalytic spliceosome |
| Component | GO:1990904 | ribonucleoprotein complex |
| Component | GO:0097526 | spliceosomal tri-snRNP complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0000387 | spliceosomal snRNP assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.11 | 0.94 |
| Trophozoite | expressed | 0.14 | 0.91 |
| Schizont | expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0909800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.659 | MFS: -2.211 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H529
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102085
Most Similar Human Ortholog: H3BT13
TM-align score: 0.97 | RMSD: 0.49
Seq Identity: 0.53 | Length: 62 / 116
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100028 | small nuclear ribonucleoprotein D3 polypeptide |
| ENSG00000286070 | novel protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 5 | 3 | 9 |
| disruptive | 4 | 4 | 2 | 9 |
| missense | 4 | 4 | 1 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 13 | 3 | 9 |
| disruptive | 5 | 18 | 17 | 34 |
| missense | 4 | 15 | 13 | 25 |
PlasmoDB Total SNPs: 100
Non-coding: 94 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 116 | Molecular Weight (kDa): 12.981
UniProt ID(s): C0H529
PDB ID(s): None
Isoelectric Point: 10.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001163 | LSM domain, eukaryotic/archaea-type |
| InterPro | IPR010920 | LSM domain superfamily |
| InterPro | IPR027141 | Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 |
| InterPro | IPR034099 | Small nuclear ribonucleoprotein Sm D3 |
| PFam | PF01423 | LSM domain, eukaryotic/archaea-type |
| Superfamily | SSF50182 | LSM domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |