Product Description: histone-lysine N-methyltransferase SET4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.1.43 (Transferred entry: 2.1.1.354)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0018024 | histone-lysine N-methyltransferase activity |
| Process | GO:0034968 | histone lysine methylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.04 | 0.98 |
| Schizont | not expressed | 0.23 | 0.86 |
| Gametocyte | not expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0910000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.468 | #Insertions: 5
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0811200)
Modification: Disrupted | RMgm-2347
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I352
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.1.1.43 | histone-lysine N-methyltransferase | BRENDA SOAP query unsuccessful |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9NRG4 | N-lysine methyltransferase SMYD2 | OrthoDB | CHEMBL3818083CHEMBL3819277US10023539, Example 1US10023539, Example 2... | |
| Q9H7B4 | Histone-lysine N-methyltransferase SMYD3 | OrthoDB | US10106510, Compound 1US10106510, Compound 2US10106510, Compound 3US10106510, Compound 4... |
Protein Length: 1114 | Molecular Weight (kDa): 131.89
UniProt ID(s): Q8I352
PDB ID(s): None
Isoelectric Point: 8.58
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | SSF82199 | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 83 | 52 | 90 |
| disruptive | 33 | 172 | 113 | 254 |
| missense | 30 | 162 | 110 | 240 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 171 | 47 | 89 |
| disruptive | 69 | 391 | 185 | 351 |
| missense | 56 | 350 | 165 | 269 |
PlasmoDB Total SNPs: 96
Non-coding: 3 | Synonymous: 50 | Nonsynonymous: 43 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 19765590 | Potential epigenetic regulatory proteins localise to distinct nuclearsub-compartments in Plasmodium falciparum. | Volz J, Carvalho TG, ..., Cowman AF | 10.1016/j.ijpara.2009.09.002 |
| 33839154 | Dynamic association of the H3K64 trimethylation mark with genes encoding exportedproteins in Plasmodium falciparum. | Jabeena CA, Govindaraju G, ..., Rajavelu A | 10.1016/j.jbc.2021.100614 |
| 34625508 | Set4 regulates stress response genes and coordinates histone deacetylases withinyeast subtelomeres | Jethmalani Y, Tran K, ..., Green EM | 10.26508/lsa.202101126 |
| 30523388 | SET domains and stress: uncovering new functions for yeast Set4 | Tran K, Green EM | 10.1007/s00294-018-0917-6 |
| 29263028 | A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance andHypoxic Gene Repression in Saccharomyces cerevisiae | Serratore ND, Baker KM, ..., Briggs SD | 10.1534/genetics.117.300554 |
| 30082318 | Set4 is a chromatin-associated protein, promotes survival during oxidativestress, and regulates stress response genes in yeast | Tran K, Jethmalani Y, Jaiswal D, Green EM | 10.1074/jbc.RA118.003078 |
| 34320248 | Adaptive local false discovery rate procedures for highly spiky data and theirapplication RNA sequencing data of yeast SET4 deletion mutants | Ramos ML, Park D, ..., Green E | 10.1002/bimj.202000256 |