Product Description: exportin-7, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005643 | nuclear pore |
| Component | GO:0005634 | nucleus |
| Function | GO:0005049 | nuclear export signal receptor activity |
| Process | GO:0009657 | plastid organization |
| Process | GO:0006611 | protein export from nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.19 | 0.90 |
| Trophozoite | expressed | 0.57 | 0.67 |
| Schizont | expressed | 0.33 | 0.79 |
| Gametocyte | expressed | 0.34 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0910100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.191 | MFS: -3.315 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0811300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H530
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102412
Most Similar Human Ortholog: E5RIW1
TM-align score: 0.92 | RMSD: 1.71
Seq Identity: 0.35 | Length: 235 / 1198
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000130227 | exportin 7 |
| ENSG00000204764 | RAN binding protein 17 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 82 | 49 | 96 |
| disruptive | 11 | 28 | 39 | 81 |
| missense | 5 | 25 | 37 | 72 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 26 | 185 | 43 | 78 |
| disruptive | 15 | 119 | 65 | 200 |
| missense | 6 | 97 | 50 | 132 |
PlasmoDB Total SNPs: 367
Non-coding: 314 | Synonymous: 43 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 1198 | Molecular Weight (kDa): 139.178
UniProt ID(s): C0H530
PDB ID(s): None
Isoelectric Point: 6.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016024 | Armadillo-type fold |
| PFam | N/A | N/A |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30726238 | A mutagenesis screen for essential plastid biogenesis genes in human malariaparasites. | Tang Y, Meister TR, ..., Yeh E | 10.1371/journal.pbio.3000136 |