About Gene List

PF3D7_0910200

Genome location: Pf3D7_09_v3:464,148..474,861(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.77 0.66
Trophozoite expressed 1.33 0.39
Schizont expressed 1.38 0.43
Gametocyte not expressed 1.26 0.41

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0910200

Resistome Missense Mutations: L2559V

Resistome Compounds with Missense Mutations: Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.058 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533736

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 33 158 79 172
disruptive 271 681 306 759
missense 160 535 252 570

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 55 299 111 213
disruptive 476 1387 503 1287
missense 289 1037 342 605

PlasmoDB Total SNPs: 741

Non-coding: 137 | Synonymous: 285 | Nonsynonymous: 317 | Stop Codon: 2

Protein Information

Protein Length: 3069 | Molecular Weight (kDa): 368.345

UniProt ID(s): Q8I350

PDB ID(s): None

Isoelectric Point: 5.11

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108