PF3D7_0910300

Genome location: Pf3D7_09_v3:475,004..477,689(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MIFLRNGFFFLFSVLTSCYINLFTQCLG

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.40	0.81
Trophozoite	expressed	0.63	0.64
Schizont	possibly expressed	0.37	0.76
Gametocyte	not expressed	0.71	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0910300

Resistome Missense Mutations: T92I, G98V, W286R

Resistome Compounds with Missense Mutations: MMV688533

Resistome # Samples with Disruptive Mutations: 6 (6 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.524 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I349

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215340

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	21	22	27
disruptive	6	45	21	59
missense	6	43	21	50

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	51	21	31
disruptive	21	88	43	115
missense	15	76	38	75

PlasmoDB Total SNPs: 156

Non-coding: 128 | Synonymous: 18 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 432 | Molecular Weight (kDa): 51.595

UniProt ID(s): Q8I349

PDB ID(s): None

Isoelectric Point: 8.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A