Product Description: selenide water dikinase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.9.3 (Selenide, water dikinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0004756 | selenide, water dikinase activity |
| Process | GO:0016260 | selenocysteine biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.96 |
| Trophozoite | possibly expressed | 0.41 | 0.75 |
| Schizont | possibly expressed | 0.18 | 0.88 |
| Gametocyte | not expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0910400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.378 | #Insertions: 7
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I348
"Best" AlphaFill ligand hit: APC (alpha,beta-methyleneadenosine-5'-triphosphate, Local RMSD=0.19) with 2YYE (Global RMSD=2.76)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.9.3 | selenide, water dikinase | AMPRNAiphosphate8-azido-ATPgamma-Thio-ATPSelenophosphatealpha,beta-methylene-ATP |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102344
Most Similar Human Ortholog: Q5T5U7
TM-align score: 0.86 | RMSD: 1.56
Seq Identity: 0.27 | Length: 89 / 1193
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000086475 | selenophosphate synthetase 1 |
| ENSG00000179918 | selenophosphate synthetase 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 70 | 41 | 83 |
| disruptive | 29 | 178 | 85 | 191 |
| missense | 22 | 170 | 81 | 171 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 135 | 53 | 87 |
| disruptive | 79 | 343 | 164 | 300 |
| missense | 58 | 298 | 145 | 228 |
PlasmoDB Total SNPs: 152
Non-coding: 71 | Synonymous: 44 | Nonsynonymous: 37 | Stop Codon: 0
Protein Length: 1193 | Molecular Weight (kDa): 140.317
UniProt ID(s): Q8I348
PDB ID(s): None
Isoelectric Point: 8.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004536 | Selenophosphate synthetase |
| InterPro | IPR010918 | PurM-like, C-terminal domain |
| InterPro | IPR016188 | PurM-like, N-terminal domain |
| InterPro | IPR036676 | PurM-like, C-terminal domain superfamily |
| InterPro | IPR036921 | PurM-like, N-terminal domain superfamily |
| PFam | PF00586 | PurM-like, N-terminal domain |
| PFam | PF02769 | PurM-like, C-terminal domain |
| Superfamily | SSF55326 | PurM-like, N-terminal domain superfamily |
| Superfamily | SSF56042 | PurM-like, C-terminal domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |