PF3D7_0910600 (YKT6.1)

Genome location: Pf3D7_09_v3:488,911..491,014(+)

Genome classification: Core

Function and Localization

Product Description: SNARE protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005794	Golgi apparatus
Component	GO:0005829	cytosol
Process	GO:0006886	intracellular protein transport
Process	GO:0018342	protein prenylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	expressed	0.06	0.96
Schizont	expressed	0.19	0.88
Gametocyte	expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0910600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.202 | MFS: -3.325 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0811700)

Relative Growth Rate: 0.06 ± 0.08
Confidence: 6.55

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I346

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139512

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	25	8	14
disruptive	3	8	4	21
missense	3	8	4	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	28	12	12
disruptive	7	22	14	49
missense	4	18	11	35

PlasmoDB Total SNPs: 178

Non-coding: 167 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 2

Protein Information

Protein Length: 199 | Molecular Weight (kDa): 23.342

UniProt ID(s): Q0ZAF8, Q8I346

PDB ID(s): None

Isoelectric Point: 8.56

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001388	Synaptobrevin
InterPro	IPR010908	Longin domain
InterPro	IPR011012	Longin-like domain superfamily
PFam	PF00957	Synaptobrevin
PFam	PF13774	Longin domain
Superfamily	SSF58038	Longin-like domain superfamily
Superfamily	SSF64356

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
21075148	Evidence for prenylation-dependent targeting of a Ykt6 SNARE in Plasmodiumfalciparum.	Ayong L, DaSilva T, ..., Chakrabarti D	10.1016/j.molbiopara.2010.11.007
37548452	Functional screening reveals Toxoplasma prenylated proteins required forendocytic trafficking and rhoptry protein sorting	Wang QQ, Sun M, ..., Long S	10.1128/mbio.01309-23