PF3D7_0911100

Genome location: Pf3D7_09_v3:504,394..509,439(+)

Genome classification: Core

Function and Localization

Product Description: START domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.74	0.78
Trophozoite	not expressed	0.14	0.92
Schizont	expressed	0.82	0.74
Gametocyte	expressed	0.57	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0911100

Resistome Missense Mutations: N173K, N175K, E1122Q

Resistome Compounds with Missense Mutations: AN13762, MMV688533

Resistome # Samples with Disruptive Mutations: 9 (7 missense, 4 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.995 | MFS: -2.67 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I341

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=2.54) with 4KV9 (Global RMSD=16.93)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121141

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	55	25	78
disruptive	34	133	79	156
missense	18	116	71	118

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	116	43	98
disruptive	75	284	150	303
missense	42	226	109	195

PlasmoDB Total SNPs: 148

Non-coding: 67 | Synonymous: 47 | Nonsynonymous: 34 | Stop Codon: 0

Protein Information

Protein Length: 1165 | Molecular Weight (kDa): 137.117

UniProt ID(s): Q8I341

PDB ID(s): None

Isoelectric Point: 9.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF55961	N/A