Product Description: spindle and kinetochore-associated protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000776 | kinetochore |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.11 | 0.92 |
| Schizont | possibly expressed | 0.07 | 0.95 |
| Gametocyte | possibly expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0911200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.143 | MFS: -3.185 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0812300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0812300)
Modification: Tagged | RMgm-5111
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I340
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104892
Most Similar Human Ortholog: Q8IYI6
TM-align score: 0.45 | RMSD: 4.21
Seq Identity: 0.06 | Length: 127 / 197
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000116903 | exocyst complex component 8 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 5 | 8 | 11 |
| disruptive | 8 | 15 | 11 | 17 |
| missense | 3 | 14 | 8 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 11 | 12 | 15 |
| disruptive | 12 | 45 | 19 | 53 |
| missense | 5 | 32 | 17 | 34 |
PlasmoDB Total SNPs: 56
Non-coding: 44 | Synonymous: 10 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 197 | Molecular Weight (kDa): 23.361
UniProt ID(s): Q8I340
PDB ID(s): None
Isoelectric Point: 7.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 36006241 | Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation | Brusini L, Dos Santos Pacheco N, ..., Brochet M | 10.1083/jcb.202111084 |