Product Description: cysteine repeat modular protein 1
SignalP Peptide: MLKFFFFFFYMFLIIYGIAT
# Transmembrane Domains: 10
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031362 | anchored component of external side of plasma membrane |
| Component | GO:0009897 | external side of plasma membrane |
| Process | GO:0030522 | intracellular receptor signaling pathway |
| Process | GO:0046907 | intracellular transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.07 | 0.96 |
| Schizont | not expressed | 0.09 | 0.94 |
| Gametocyte | possibly expressed | 0.19 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0911300
Resistome Missense Mutations: G165A
Resistome Compounds with Missense Mutations: MMV688533
Resistome # Samples with Disruptive Mutations: 6 (4 missense, 4 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.56 | #Insertions: 10
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1445700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0812400)
Modification: Disrupted | RMgm-2356
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 134 | 86 | 216 |
| disruptive | 122 | 258 | 153 | 399 |
| missense | 90 | 221 | 139 | 332 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 32 | 278 | 137 | 248 |
| disruptive | 209 | 583 | 265 | 694 |
| missense | 141 | 461 | 219 | 453 |
PlasmoDB Total SNPs: 251
Non-coding: 16 | Synonymous: 135 | Nonsynonymous: 100 | Stop Codon: 0
Protein Length: 3313 | Molecular Weight (kDa): 391.321
UniProt ID(s): Q8I339
PDB ID(s): None
Isoelectric Point: 9.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000001 | Kringle |
| InterPro | IPR011641 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| InterPro | IPR013806 | Kringle-like fold |
| InterPro | IPR018056 | Kringle, conserved site |
| PFam | PF00051 | Kringle |
| PFam | PF07699 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| Superfamily | SSF57440 | Kringle-like fold |
| Superfamily | SSF57586 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 17253978 | Plasmodium cysteine repeat modular proteins 1-4: complex proteins with rolesthroughout the malaria parasite life cycle. | Thompson J, Fernandez-Reyes D, ..., Waters AP | 10.1111/j.1462-5822.2006.00885.x |