PF3D7_0911400

Genome location: Pf3D7_09_v3:521,554..526,248(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.54	0.75
Trophozoite	expressed	0.77	0.58
Schizont	expressed	0.17	0.90
Gametocyte	possibly expressed	0.50	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0911400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.768 | MFS: -1.165 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I338

"Best" AlphaFill ligand hit: NOJ (moranoline, Local RMSD=1.86) with 7VKZ (Global RMSD=13.61)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533464

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	52	34	87
disruptive	30	159	79	226
missense	24	146	72	208

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	109	55	96
disruptive	64	328	149	331
missense	39	288	126	263

PlasmoDB Total SNPs: 144

Non-coding: 51 | Synonymous: 54 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 1218 | Molecular Weight (kDa): 147.227

UniProt ID(s): Q8I338

PDB ID(s): None

Isoelectric Point: 7.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007244	-alpha-acetyltransferase 35, NatC auxiliary subunit
PFam	PF04112	-alpha-acetyltransferase 35, NatC auxiliary subunit
Superfamily	N/A	N/A