PF3D7_0911500

Genome location: Pf3D7_09_v3:526,449..528,094(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	nd	nd
Trophozoite	not expressed	nd	nd
Schizont	not expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0911500.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.915 | MFS: -2.015 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZX57

"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=0.04) with 1SK6 (Global RMSD=25.66)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_167111

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	15	5	13
disruptive	7	18	9	31
missense	7	17	9	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	20	12	10
disruptive	11	49	31	47
missense	9	41	22	35

PlasmoDB Total SNPs: 56

Non-coding: 50 | Synonymous: 2 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 184 | Molecular Weight (kDa): 21.982

UniProt ID(s): C0H533

PDB ID(s): None

Isoelectric Point: 7.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A