About Gene List

PF3D7_0911600

Genome location: Pf3D7_09_v3:528,858..532,077(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.99
Trophozoite not expressed 0.29 0.81
Schizont possibly expressed 0.22 0.86
Gametocyte expressed 0.40 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0911600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.403 | MFS: -2.543 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H534

"Best" AlphaFill ligand hit: AE3 (2-(2-ethoxyethoxy)ethanol, Local RMSD=2.18) with 6U0O (Global RMSD=16.55)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533019

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 29 13 41
disruptive 22 84 39 121
missense 17 72 36 88

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 57 25 39
disruptive 47 188 82 179
missense 33 149 59 97

PlasmoDB Total SNPs: 147

Non-coding: 88 | Synonymous: 34 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 510 | Molecular Weight (kDa): 61.134

UniProt ID(s): C0H534

PDB ID(s): None

Isoelectric Point: 10.48

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895