PF3D7_0911800

Genome location: Pf3D7_09_v3:535,699..536,950(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.13	0.93
Trophozoite	not expressed	0.49	0.73
Schizont	possibly expressed	0.93	0.53
Gametocyte	not expressed	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0911800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.014 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I334

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533061

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	14	6	12
disruptive	4	37	18	57
missense	4	35	17	54

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	20	13	20
disruptive	15	94	45	74
missense	10	82	37	53

PlasmoDB Total SNPs: 56

Non-coding: 49 | Synonymous: 3 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 276 | Molecular Weight (kDa): 32.932

UniProt ID(s): Q8I334

PDB ID(s): None

Isoelectric Point: 10.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A