About Gene List

PF3D7_0911900 (ICP)

Genome location: Pf3D7_09_v3:536,963..540,283(-)

Genome classification: Core

Function and Localization

Product Description: falstatin

SignalP Peptide: MNLLVFFCFFLLSCIVHLSRC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol
Component GO:0030430 host cell cytoplasm
Component GO:0031982 vesicle
Function GO:0004869 cysteine-type endopeptidase inhibitor activity
Process GO:0048870 cell motility
Process GO:0044409 entry into host

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 2.08 0.21
Trophozoite expressed 1.39 0.33
Schizont expressed 0.91 0.52
Gametocyte expressed 1.62 0.27

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0911900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.814 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0813000)

  • Relative Growth Rate: 0.32 ± 0.42
  • Confidence: 3.12

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0813000)

Modification: Tagged | RMgm-1483

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I333

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532443

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 28 17 28
disruptive 12 48 32 92
missense 11 45 31 91

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 59 25 31
disruptive 26 109 55 145
missense 21 99 52 119

PlasmoDB Total SNPs: 257

Non-coding: 225 | Synonymous: 18 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 413 | Molecular Weight (kDa): 46.958

UniProt ID(s): Q2PZB1, Q8I333

PDB ID(s): None

Isoelectric Point: 6.66

Protein Domain Annotations:

Source Family ID Description
InterPro IPR024321 Protease inhibitor, falstatin
InterPro IPR036331 Chagasin-like superfamily
PFam PF12628 Protease inhibitor, falstatin
Superfamily SSF141066 Chagasin-like superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
17083274 Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitateserythrocyte invasion. Pandey KC, Singh N, ..., Rosenthal PJ 10.1371/journal.ppat.0020117
24281719 Inhibitor of cysteine proteases is critical for motility and infectivity ofPlasmodium sporozoites. Boysen KE, Matuschewski K 10.1128/mBio.00874-13
26292257 Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for VaccineDevelopment. Aguiar JC, Bolton J, ..., Richie TL 10.1371/journal.pone.0136109