PF3D7_0912000

Genome location: Pf3D7_09_v3:540,903..546,278(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.34	0.84
Trophozoite	expressed	0.69	0.62
Schizont	expressed	0.19	0.89
Gametocyte	not expressed	0.49	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0912000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.186 | MFS: -3.256 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I332

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533131

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	87	52	100
disruptive	78	232	131	313
missense	58	215	126	286

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	35	165	73	119
disruptive	150	471	218	394
missense	107	411	199	310

PlasmoDB Total SNPs: 308

Non-coding: 158 | Synonymous: 85 | Nonsynonymous: 65 | Stop Codon: 0

Protein Information

Protein Length: 1568 | Molecular Weight (kDa): 188.686

UniProt ID(s): Q8I332

PDB ID(s): None

Isoelectric Point: 9.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010301	Nucleolar, Nop52
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104