PF3D7_0912100

Genome location: Pf3D7_09_v3:546,289..548,478(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.28	0.86
Trophozoite	expressed	0.28	0.83
Schizont	expressed	0.05	0.97
Gametocyte	expressed	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0912100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.209 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I331

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=5.99) with 3A4L (Global RMSD=21.81)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103585

Most Similar Human Ortholog: E9PQB8

TM-align score: 0.66 | RMSD: 2.51

Seq Identity: 0.15 | Length: 142 / 433

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000174276	zinc finger HIT-type containing 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	20	15	23
disruptive	51	111	38	84
missense	21	61	25	54

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	39	22	26
disruptive	81	171	55	112
missense	30	105	38	65

PlasmoDB Total SNPs: 165

Non-coding: 84 | Synonymous: 45 | Nonsynonymous: 36 | Stop Codon: 0

Protein Information

Protein Length: 433 | Molecular Weight (kDa): 52.422

UniProt ID(s): Q8I331

PDB ID(s): None

Isoelectric Point: 6.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007529	Zinc finger, HIT-type
InterPro	IPR039646	Zinc finger HIT domain-containing protein 2
PFam	PF04438	Zinc finger, HIT-type
Superfamily	SSF144232	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104