About Gene List

PF3D7_0912200

Genome location: Pf3D7_09_v3:549,085..550,446(-)

Genome classification: Core

Function and Localization

Product Description: membrane protein S54, putative

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane
Component GO:0005886 plasma membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.07 0.97
Trophozoite not expressed 0.08 0.96
Schizont not expressed 0.03 0.98
Gametocyte expressed 0.39 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0912200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.147 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I330

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179338

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 38 20 39
disruptive 11 49 20 80
missense 11 48 20 71

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 63 26 47
disruptive 20 104 46 116
missense 17 93 42 94

PlasmoDB Total SNPs: 34

Non-coding: 0 | Synonymous: 16 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 453 | Molecular Weight (kDa): 54.275

UniProt ID(s): Q8I330

PDB ID(s): None

Isoelectric Point: 9.57

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095