About Gene List

PF3D7_0912400

Genome location: Pf3D7_09_v3:551,020..555,071(-)

Genome classification: Core

Function and Localization

Product Description: alkaline phosphatase, putative

SignalP Peptide: MNTCIKLIFAFFIFIKYGRC

# Transmembrane Domains: 1

EC Numbers: 3.1.3.1 (Alkaline phosphatase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0005634 nucleus
Component GO:0005886 plasma membrane
Component GO:0020003 symbiont-containing vacuole

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.16 0.92
Trophozoite expressed 0.85 0.55
Schizont expressed 0.22 0.85
Gametocyte expressed 0.41 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0912400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.994 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I328

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.1.3.1 alkaline phosphatase BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106376

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 1
missense 0 0 0 0

PlasmoDB Total SNPs: 370

Non-coding: 340 | Synonymous: 25 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 446 | Molecular Weight (kDa): 52.705

UniProt ID(s): Q8I328

PDB ID(s): None

Isoelectric Point: 9.54

Protein Domain Annotations:

Source Family ID Description
InterPro IPR018946 PhoD-like phosphatase, metallophosphatase domain
PFam PF09423 PhoD-like phosphatase, metallophosphatase domain
Superfamily SSF56300 N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
28784333 Identification of novel parasitophorous vacuole proteins in P. falciparumparasites using BioID. Khosh-Naucke M, Becker J, ..., Spielmann T 10.1016/j.ijmm.2017.07.007
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596