Product Description: SAP domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0016973 | poly(A)+ mRNA export from nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.81 | 0.62 |
| Trophozoite | expressed | 0.88 | 0.53 |
| Schizont | possibly expressed | 0.29 | 0.81 |
| Gametocyte | not expressed | 0.87 | 0.54 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0912500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.21 | MFS: -2.795 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H535
"Best" AlphaFill ligand hit: 1S6 (oxacillin, bound form, Local RMSD=0.64) with 4MLL (Global RMSD=24.32)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103733
Most Similar Human Ortholog: F8VS12
TM-align score: 0.78 | RMSD: 1.54
Seq Identity: 0.30 | Length: 46 / 288
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000205323 | SAP domain containing ribonucleoprotein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 18 | 9 | 25 |
| disruptive | 8 | 34 | 17 | 50 |
| missense | 8 | 33 | 17 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 32 | 15 | 25 |
| disruptive | 10 | 83 | 44 | 83 |
| missense | 9 | 71 | 39 | 55 |
PlasmoDB Total SNPs: 161
Non-coding: 139 | Synonymous: 13 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 288 | Molecular Weight (kDa): 33.185
UniProt ID(s): C0H535
PDB ID(s): None
Isoelectric Point: 10.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003034 | SAP domain |
| InterPro | IPR036361 | SAP domain superfamily |
| PFam | PF02037 | SAP domain |
| Superfamily | SSF68906 | SAP domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |