PF3D7_0913000

Genome location: Pf3D7_09_v3:568,887..570,663(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.87	0.60
Trophozoite	expressed	0.79	0.58
Schizont	expressed	0.16	0.90
Gametocyte	possibly expressed	0.41	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0913000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.805 | MFS: -2.257 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0814000)

Relative Growth Rate: 0.09 ± 0.08
Confidence: 6.43

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I322

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125522

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	2	13
disruptive	1	11	7	22
missense	1	11	6	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	11	9	8
disruptive	2	35	18	37
missense	1	28	17	27

PlasmoDB Total SNPs: 108

Non-coding: 103 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 147 | Molecular Weight (kDa): 17.359

UniProt ID(s): Q8I322

PDB ID(s): None

Isoelectric Point: 10.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019434	Uncharacterised protein family UPF0642
PFam	PF10338	Uncharacterised protein family UPF0642
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104