PF3D7_0913100

Genome location: Pf3D7_09_v3:571,031..573,349(-)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.22	0.86
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0913100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.132 | MFS: -2.914 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0814100)

Relative Growth Rate: 0.12 ± 0.09
Confidence: 6.31

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I321

"Best" AlphaFill ligand hit: LMR (l-malate, Local RMSD=0.82) with 4KUF (Global RMSD=17.12)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532567

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	51	16	48
disruptive	29	112	57	144
missense	28	105	54	130

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	87	34	49
disruptive	57	241	113	176
missense	51	204	95	133

PlasmoDB Total SNPs: 69

Non-coding: 0 | Synonymous: 35 | Nonsynonymous: 34 | Stop Codon: 0

Protein Information

Protein Length: 772 | Molecular Weight (kDa): 92.022

UniProt ID(s): Q8I321

PDB ID(s): None

Isoelectric Point: 9.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A