Product Description: elongation factor, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003746 | translation elongation factor activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | not expressed | 0.06 | 0.96 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | not expressed | 0.24 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0913400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.132 | MFS: -2.705 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0814400)
Modification: Tagged | RMgm-4973
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I318
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 9 | 4 | 8 |
| disruptive | 1 | 7 | 2 | 22 |
| missense | 1 | 7 | 1 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 16 | 3 | 9 |
| disruptive | 4 | 16 | 12 | 43 |
| missense | 4 | 11 | 11 | 34 |
PlasmoDB Total SNPs: 22
Non-coding: 19 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 168 | Molecular Weight (kDa): 19.22
UniProt ID(s): Q8I318
PDB ID(s): None
Isoelectric Point: 9.06
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001059 | Translation elongation factor P/YeiP, central |
| InterPro | IPR008991 | Translation protein SH3-like domain superfamily |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| InterPro | IPR013185 | Translation elongation factor, KOW-like |
| InterPro | IPR020599 | Translation elongation factor P/YeiP |
| PFam | PF01132 | Translation elongation factor P/YeiP, central |
| PFam | PF08207 | Translation elongation factor, KOW-like |
| Superfamily | SSF50104 | Translation protein SH3-like domain superfamily |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |