PF3D7_0913600

Genome location: Pf3D7_09_v3:584,541..588,762(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.81	0.57
Schizont	not expressed	0.46	0.74
Gametocyte	possibly expressed	0.81	0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0913600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.142 | MFS: -2.899 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I316

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533465

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	61	33	75
disruptive	56	208	90	212
missense	39	183	83	186

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	112	43	92
disruptive	113	337	162	261
missense	77	294	141	214

PlasmoDB Total SNPs: 225

Non-coding: 120 | Synonymous: 45 | Nonsynonymous: 59 | Stop Codon: 1

Protein Information

Protein Length: 1231 | Molecular Weight (kDa): 147.867

UniProt ID(s): Q8I316

PDB ID(s): None

Isoelectric Point: 5.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A