Product Description: phospholipid or glycerol acyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: 2.3.1.- (Transferring groups other than amino-acyl groups.)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.41 | 0.80 |
| Trophozoite | expressed | 0.21 | 0.87 |
| Schizont | expressed | 0.21 | 0.85 |
| Gametocyte | possibly expressed | 0.26 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0914200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.238 | MFS: -2.746 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_0818500)
Modification: Tagged | RMgm-981
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I310
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.- | Ex: [myelin-proteolipid] O-palmitoyltransferase | CoAKClArgATPADPEDTAMgCl2CaCl2MnCl2AgNO3CoCl2FeSO4... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100894
Most Similar Human Ortholog: Q8NF37
TM-align score: 0.65 | RMSD: 3.52
Seq Identity: 0.17 | Length: 313 / 418
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000087253 | lysophosphatidylcholine acyltransferase 2 |
| ENSG00000153395 | lysophosphatidylcholine acyltransferase 1 |
| ENSG00000275079 | lysophosphatidylcholine acyltransferase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 33 | 17 | 26 |
| disruptive | 5 | 12 | 12 | 26 |
| missense | 5 | 12 | 11 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 56 | 19 | 23 |
| disruptive | 8 | 48 | 29 | 96 |
| missense | 5 | 32 | 27 | 57 |
PlasmoDB Total SNPs: 300
Non-coding: 285 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 418 | Molecular Weight (kDa): 49.339
UniProt ID(s): Q8I310
PDB ID(s): None
Isoelectric Point: 9.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002123 | Phospholipid/glycerol acyltransferase |
| PFam | PF01553 | Phospholipid/glycerol acyltransferase |
| Superfamily | SSF69593 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 24330260 | Enzymes involved in plastid-targeted phosphatidic acid synthesis are essentialfor Plasmodium yoelii liver-stage development. | Lindner SE, Sartain MJ, ..., Vaughan AM | 10.1111/mmi.12485 |