About Gene List

PF3D7_0914400 (KIC3)

Genome location: Pf3D7_09_v3:617,808..619,842(+)

Genome classification: Core

Function and Localization

Product Description: protein KIC3

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.02 0.99
Trophozoite possibly expressed 0.07 0.95
Schizont expressed 0.57 0.67
Gametocyte expressed 0.92 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0914400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.342 | MFS: -4.094 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I308

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.46) with 5Z68 (Global RMSD=24.50)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109075

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 18 9 13
disruptive 1 4 5 10
missense 1 4 5 7

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 28 9 26
disruptive 3 27 16 48
missense 2 17 16 29

PlasmoDB Total SNPs: 112

Non-coding: 107 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 249 | Molecular Weight (kDa): 28.413

UniProt ID(s): Q8I308

PDB ID(s): None

Isoelectric Point: 6.36

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108