PF3D7_0914500

Genome location: Pf3D7_09_v3:620,655..626,568(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.28	0.86
Trophozoite	possibly expressed	0.91	0.53
Schizont	expressed	0.74	0.60
Gametocyte	not expressed	0.78	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0914500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.156 | MFS: -2.851 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0815500)

Modification: Other | RMgm-412

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I307

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532616

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	105	52	141
disruptive	77	359	210	449
missense	66	329	191	388

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	34	212	70	149
disruptive	153	767	300	605
missense	113	665	255	431

PlasmoDB Total SNPs: 285

Non-coding: 71 | Synonymous: 108 | Nonsynonymous: 106 | Stop Codon: 0

Protein Information

Protein Length: 1728 | Molecular Weight (kDa): 204.655

UniProt ID(s): Q8I307

PDB ID(s): None

Isoelectric Point: 8.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A