PF3D7_0914600 (ELF1)

Genome location: Pf3D7_09_v3:627,065..629,120(+)

Genome classification: Core

Function and Localization

Product Description: transcription elongation factor 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0008023	transcription elongation factor complex
Function	GO:0000993	RNA polymerase II complex binding
Process	GO:0048096	chromatin-mediated maintenance of transcription
Process	GO:0006368	transcription elongation from RNA polymerase II promoter

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.56	0.72
Trophozoite	expressed	0.69	0.61
Schizont	possibly expressed	0.66	0.60
Gametocyte	possibly expressed	0.67	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0914600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.134 | MFS: -3.385 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I306

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101618

Most Similar Human Ortholog: P60002

TM-align score: 0.77 | RMSD: 1.35

Seq Identity: 0.41 | Length: 68 / 111

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000130165	elongation factor 1 homolog

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 183

Non-coding: 176 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 111 | Molecular Weight (kDa): 12.837

UniProt ID(s): Q8I306

PDB ID(s): None

Isoelectric Point: 8.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007808	Transcription elongation factor 1
PFam	PF05129	Transcription elongation factor 1
Superfamily	SSF57783	N/A