PF3D7_0914800

Genome location: Pf3D7_09_v3:632,540..635,285(-)

Genome classification: Core

Function and Localization

Product Description: GINS complex subunit Psf3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.27	0.82
Schizont	expressed	0.28	0.80
Gametocyte	expressed	0.78	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0914800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -3.152 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1402400)

Relative Growth Rate: 0.98 ± 0.12
Confidence: 5.68

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I304

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_136404

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	1
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 217

Non-coding: 208 | Synonymous: 5 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 208 | Molecular Weight (kDa): 24.844

UniProt ID(s): Q8I304

PDB ID(s): None

Isoelectric Point: 5.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010492	GINS complex, subunit Psf3
InterPro	IPR036224	GINS, helical bundle-like domain superfamily
PFam	N/A	N/A
Superfamily	SSF158573	GINS, helical bundle-like domain superfamily