PF3D7_0914900

Genome location: Pf3D7_09_v3:635,647..639,564(+)

Genome classification: Core

Function and Localization

Product Description: BSD-domain protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.15	0.92
Trophozoite	not expressed	0.47	0.72
Schizont	not expressed	0.67	0.60
Gametocyte	not expressed	0.51	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0914900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.507 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I303

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=14.63) with 2PML (Global RMSD=27.22)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533506

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	44	23	47
disruptive	22	118	70	180
missense	21	104	64	151

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	69	31	66
disruptive	39	286	101	254
missense	34	239	74	155

PlasmoDB Total SNPs: 204

Non-coding: 132 | Synonymous: 37 | Nonsynonymous: 34 | Stop Codon: 1

Protein Information

Protein Length: 709 | Molecular Weight (kDa): 84.017

UniProt ID(s): Q8I303

PDB ID(s): None

Isoelectric Point: 4.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005607	BSD domain
PFam	PF03909	BSD domain
Superfamily	SSF140383	N/A