Product Description: SUMO-conjugating enzyme UBC9
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 6.3.2.19 (Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0061656 | SUMO conjugating enzyme activity |
| Process | GO:0016925 | protein sumoylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.18 | 0.91 |
| Trophozoite | expressed | 0.32 | 0.79 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.33 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0915100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0816100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I301
"Best" AlphaFill ligand hit: BU3 ((r,r)-2,3-butanediol, Local RMSD=0.25) with 1Z2U (Global RMSD=1.99)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 6.3.2.19 | ubiquitin-protein ligase | No BRENDA inhibitors |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P63279 | SUMO-conjugating enzyme UBC9 | Homo sapiens | OMA, OrthoDB | MLS000033902MLS000028424MLS000068755MLS000079922... |
Ortholog Group (OrthoMCL): OG6_101514
Most Similar Human Ortholog: P63279
TM-align score: 0.97 | RMSD: 0.91
Seq Identity: 0.60 | Length: 157 / 159
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000103275 | ubiquitin conjugating enzyme E2 I |
Protein Length: 159 | Molecular Weight (kDa): 18.19
UniProt ID(s): Q8I301
Isoelectric Point: 8.24
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000608 | Ubiquitin-conjugating enzyme E2 |
| InterPro | IPR016135 | Ubiquitin-conjugating enzyme/RWD-like |
| InterPro | IPR023313 | Ubiquitin-conjugating enzyme, active site |
| InterPro | IPR027230 | SUMO-conjugating enzyme Ubc9 |
| PFam | PF00179 | Ubiquitin-conjugating enzyme E2 |
| Superfamily | SSF54495 | Ubiquitin-conjugating enzyme/RWD-like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 96
Non-coding: 90 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23943616 | Identification of biochemically distinct properties of the smallubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum. | Reiter K, Mukhopadhyay D, ..., Matunis MJ | 10.1074/jbc.M113.498410 |