About Gene List

PF3D7_0915300

Genome location: Pf3D7_09_v3:646,547..649,563(-)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.09 0.96
Trophozoite expressed 0.26 0.85
Schizont expressed 0.03 0.98
Gametocyte not expressed 0.22 0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0915300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.015 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0816300)

Modification: Tagged | RMgm-4464

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2Z9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156414

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 47 30 65
disruptive 23 135 85 178
missense 15 121 75 159

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 92 48 69
disruptive 58 267 133 232
missense 42 226 117 171

PlasmoDB Total SNPs: 132

Non-coding: 74 | Synonymous: 30 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 721 | Molecular Weight (kDa): 85.408

UniProt ID(s): Q8I2Z9

PDB ID(s): None

Isoelectric Point: 9.35

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30102371 Identification of clustered organellar short (cos) RNAs and of a conserved familyof organellar RNA-binding proteins, the heptatricopeptide repeat proteins, in themalaria parasite. Hillebrand A, Matz JM, ..., Schmitz-Linneweber C 10.1093/nar/gky710