PF3D7_0915600

Genome location: Pf3D7_09_v3:659,929..661,258(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	1.06	0.54
Trophozoite	expressed	0.58	0.69
Schizont	possibly expressed	0.14	0.92
Gametocyte	possibly expressed	0.39	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0915600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.975 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2Z6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533046

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	9	4	15
disruptive	4	32	36	65
missense	4	31	33	56

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	22	3	14
disruptive	14	110	37	88
missense	10	91	33	49

PlasmoDB Total SNPs: 47

Non-coding: 27 | Synonymous: 16 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 238 | Molecular Weight (kDa): 28.482

UniProt ID(s): Q8I2Z6

PDB ID(s): None

Isoelectric Point: 10.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A