PF3D7_0915800 (GLTP)

Genome location: Pf3D7_09_v3:663,573..664,607(+)

Genome classification: Core

Function and Localization

Product Description: glycolipid transfer protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Component	GO:0016020	membrane
Function	GO:1902387	ceramide 1-phosphate binding
Function	GO:1902388	ceramide 1-phosphate transfer activity
Function	GO:0008289	lipid binding
Process	GO:0035627	ceramide transport
Process	GO:0120009	intermembrane lipid transfer

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.05	0.96
Schizont	possibly expressed	0.08	0.94
Gametocyte	expressed	0.68	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0915800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.174 | MFS: -3.012 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0816800)

Relative Growth Rate: 0.98 ± 0.08
Confidence: 6.55

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0816800)

Modification: Disrupted | RMgm-2368

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2Z4

"Best" AlphaFill ligand hit: LNK (pentane, Local RMSD=0.03) with 2EVL (Global RMSD=4.78)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101874

Most Similar Human Ortholog: Q9NZD2

TM-align score: 0.88 | RMSD: 1.98

Seq Identity: 0.20 | Length: 202 / 217

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000106086	pleckstrin homology domain containing A8
ENSG00000139433	glycolipid transfer protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	15	10	15
disruptive	10	15	4	23
missense	10	15	4	21

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	31	8	19
disruptive	14	27	20	53
missense	14	19	17	41

PlasmoDB Total SNPs: 35

Non-coding: 19 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 217 | Molecular Weight (kDa): 25.182

UniProt ID(s): Q8I2Z4

PDB ID(s): None

Isoelectric Point: 8.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR014830	Glycolipid transfer protein domain
InterPro	IPR036497	Glycolipid transfer protein superfamily
PFam	PF08718	Glycolipid transfer protein domain
Superfamily	SSF110004	Glycolipid transfer protein superfamily