PF3D7_0916000 (MFS2)

Genome location: Pf3D7_09_v3:666,577..671,763(-)

Genome classification: Core

Function and Localization

Product Description: major facilitator superfamily domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.09	0.95
Trophozoite	expressed	0.15	0.91
Schizont	expressed	1.71	0.28
Gametocyte	expressed	1.28	0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0916000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.334 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0817000)

Relative Growth Rate: 0.96 ± 0.13
Confidence: 5.48

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0820300)

Modification: Disrupted | RMgm-4770

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2Z2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107747

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	91	44	98
disruptive	56	212	93	264
missense	41	169	80	223

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	198	73	116
disruptive	125	463	225	473
missense	76	370	179	297

PlasmoDB Total SNPs: 156

Non-coding: 32 | Synonymous: 78 | Nonsynonymous: 46 | Stop Codon: 0

Protein Information

Protein Length: 1379 | Molecular Weight (kDa): 160.369

UniProt ID(s): Q8I2Z2

PDB ID(s): None

Isoelectric Point: 8.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR036259	MFS transporter superfamily
PFam	PF07690	Major facilitator superfamily
Superfamily	SSF103473	MFS transporter superfamily

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095